CD8A and neoplasm: A substantial number of scientific findings highlights the importance of Type I IFN signaling in the maturation and activation of DCs by enhancing their ability to cross-prime and activate tumor-specific CD8+ T cells through the upregulation of the costimulatory molecules MHC-I, MHC-II, CD40, CD80, CD86 [173] and the retention of antigenic particles engulfed from apoptotic cells [174].