Furthermore, a recent breakthrough by Frank and colleagues established an interesting link between mitotic cell cycle arrest and IFN-β in the promotion of necroptosis, a programmed form of necrosis, in apoptosis-resistant cancer cells through the phosphorylation of receptor interacting serine/threonine kinase 3 (RIPK3 also known as RIP3) [149]. The gene discussed is RIPK3; the disease is cancer.