TYMS and malignant colon neoplasm: Recent studies on other plant-derived small molecules include the traditional Chinese medicine herbal formula Huang Qin Ge Gen Tang that modulates the E2F1/TS pathway, green tea extracted polyphenol epigallocatechin gallate that upregulates miR-155 to suppress MDR1 expression, β-elemene that can induce pro-death autophagy, and xanthonoid α-mangostin that have been successful in enhancing 5-FU cytotoxicity in colon cancer cells [59,81,301,302].