In colon cancer, dysregulation that elicits genomic instability causing tumor initiation can derive from gene promoter CpG island methylation as observed in tumor-suppressors Krüeppel-like factor 6 (KLF6), KLF4, and zinc finger protein 726 (ZNF726) silencing; through direct hypermethylation of one allele demonstrated in human mutL homolog 1 (hMLH1) and cyclin-dependent kinase inhibitor 2A (CDKN2A); and through DNA hypomethylation such as in the case of LINC00460 that promotes metastasis [172,173,174,175]. The gene discussed is CDKN2A; the disease is malignant colon neoplasm.