MAPK8 and colonic neoplasm: Other small molecule inhibitors studied to be effective in reversing 5-FU in colon cancer cells may include phospholipase A2 inhibitor quinacrine that enhances c-Jun N-terminal kinase (JNK1)-dependent Nrf2 degradation, and DNA methyltransferase inhibitor decitabine that demethylates TYMP promoter (Table 4) [285,286].