When FK866 was introduced into CRC cells, nicotinamide phosphoribosyltransferase (NAMPT) was inhibited, and consequently, Sirtuin 1 (SIRT1)—a histone deacetylase that deacetylates the lysine residue 382 of TP53 to inhibit its activity—was reduced [72]. Here, SIRT1 is linked to colorectal carcinoma.