One of the most studied ncRNA in CRC is the HOX transcript antisense intergenic RNA (HOTAIR), which is a lncRNA that binds in trans with polycomb repressive complex 2 (PRC2) and increases the expression of several genes involved in invasion and metastasis of CRC, such as vimentin and E-cadherin [16]. This evidence concerns the gene VIM and colorectal carcinoma.