BDNF and Stroke: Additionally, overweight and obesity, hyperhomocisteinemia, aging, and some genetic factors can increase the risk of stroke outbreak, while it is diminished by routine physical activity thanks to exercise-induced increase in the expression of neuroprotective factors such as endothelial nitric oxide synthetase, brain-derived neurotrophic factor (BDNF), and insulin-like growth factor 1 (IGF-1) [2].