In 23 patients (3.5%), autosomal recessive (AR) deficiencies (IRF7 and IFNAR1) and autosomal dominant (AD) deficiencies (TLR3, UNC93B1, TICAM1, TBK1, IRF3, IRF7, IFNAR1 and IFNAR2) were identified and 10 of these patients had low serum IFN-α levels. This evidence concerns the gene IRF7 and Alzheimer disease.