At 6 h after weaning from CPB, patients with AKI had higher serum IL-6 (M = 128.58 (95.53–255.2) ng/mL vs. 86.62 (57.36–115.84) ng/mL in the control group, p = 0.005), IL-8 (M = 31.02 (17.89–41.66) ng/mL vs. 12.09 (8.74–22.27) ng/mL in the control group, p = 0.016) and TNF-α (M = 6.43 (4.5–7.08) ng/mL vs. 3.9 (2.7–4.52) ng/mL in the control group, p = 0.002). The gene discussed is CXCL8; the disease is acute kidney injury.