Patients who suffered from CSA-AKI and experienced long-term postoperative kidney function impairment had a significantly lower hematocrit level in the 2nd measurement during CPB (approximately 45 min after the initiation of CPB; M = 18 (18–18)% vs. 25 (22–27)% in the control group, p = 0.006) and a higher preoperative serum IL-8 concentration (M = 7.89 (5.25–14.85) ng/mL vs. 4.73 (3.39–5.59) ng/mL in the control group, p = 0.048). The gene discussed is CXCL8; the disease is acute kidney injury.