For this reason, the aim of this study was to assess the utility of specific inflammation and kidney injury biomarkers (IL-6, IL-8, TNF-α, NGAL, KIM-1, IL-18, MMP-9 and TIMP-1) in the early diagnostic of CSA-AKI and in the prognosis of long-term postoperative kidney function. This evidence concerns the gene IL18 and acute kidney injury.