Higher serum TNF-α concentration 6 h after weaning from CPB was observed in patients who developed CSA-AKI (M = 6.43 (4.5–7.08) ng/mL vs. 3.9 (2.7–4.52) ng/mL in the control group, p = 0.002) and in patients who underwent intraoperative hemofiltration (M = 5.1 (3.6–6.77) ng/mL vs. 3.98 (2.56–4.52) ng/mL in the control group, p = 0.020). The gene discussed is TNF; the disease is acute kidney injury.