AR and prostate neoplasm: The other major extrahepatic P450 isoform expressed in normal and prostate tumor is CYP1A1 [36], bergamottin is a competitive inhibitor of CYP1A1 and can aid in cancer chemoprevension due to CYP1A1s role in carcinogenesis, this inhbitory effect is independent of bergamottins affect on CYP3A5 and AR [33].