These genes along with their activation values Eq (3) for melanoma (MEL) are, GPNMB (MEL activation = 18.59), UBL3 (MEL activation = 1.39), AP1S2 (MEL activation = 1.28), RAB38 (MEL activation = 0.91), EDNRB (MEL activation = 0.55), JUN (MEL activation = 0.34), and C1orf21 (MEL activation = -0.13). This evidence concerns the gene EDNRB and melanoma.