For melanoma specific themes, Fig 7 shows that TRPM7 is associated with “actin binding,” DPYSL2 is associated with “microtubule binding” and “regulation of axon extension”, and LYST is associated with “microtubule cytoskeleton.” For all module 2 biomarkers the average number of CTD references relating each gene to melanoma = 30 and the average CTD inference score per gene = 17. The gene discussed is LYST; the disease is melanoma.