High expression genes (activation > 1.5) in module 1 that do show statistically significant tumor-normal expression differences (Fig 6 and S7 File) are: CD44 (PULM activation = 5.97, normal activation = 1.17, p = 3.42E-02), FAT1 (PULM activation = 5.95, normal activation = 1.59, p = 3.26E-02), SDC1 (PULM activation = 2.78, Normal activation = 0.54, p = 3.56E-02) and MYOF (PULM activation = 1.66, Normal activation = 0.12, p = 3.56E-02). The gene discussed is CD44; the disease is neoplasm.