Annotations showing the relationship of SAMSN1 to membrane ruffling and IMPDH2 to control by MYC which in B-cell lymphoma is constitutively activated by fusion to IGH, implies that up regulation of SAMSN1 and IMPDH2 found here is associated with B-cell lymphoma and not necessarily tissue specific transcription. This evidence concerns the gene SAMSN1 and B-cell non-Hodgkin lymphoma.