These targets are associated with a variety of annotations which include “extracellular exosome”, “clathrin-coated pit”, “trans-Golgi network membrane”, “signal transduction”, and “axon regeneration.” For osteosarcoma, high novelty targets are COL16A1 and KDELR2, and are associated with annotations that include “extracellular exosome”, “endoplasmic reticulum lumen”, “Golgi membrane”, “cell adhesion”, “extracellular matrix organization”, and “integrin mediated signaling pathway”. This evidence concerns the gene KDELR2 and osteosarcoma.