Genes satisfying these constraints are: CD44, FAT1, SDC1, and MYOF for PULM, SPPL2A, CHL1, AP4E1, SECISBP2L, and COPS2 for MEL, COL16A1 for OSA, and MDN1 and CD22 for BLSA. Here, SPPL2A is linked to obstructive sleep apnea syndrome.