Annotations showing the relationship of SAMSN1 to membrane ruffling and IMPDH2 to control by MYC which in B-cell lymphoma is constitutively activated by fusion to IGH, implies that up regulation of SAMSN1 and IMPDH2 found here is associated with B-cell lymphoma and not necessarily tissue specific transcription. The gene discussed is MYC; the disease is B-cell non-Hodgkin lymphoma.