Genes satisfying these constraints are: CD44, FAT1, SDC1, and MYOF for PULM, SPPL2A, CHL1, AP4E1, SECISBP2L, and COPS2 for MEL, COL16A1 for OSA, and MDN1 and CD22 for BLSA. This evidence concerns the gene COL16A1 and obstructive sleep apnea syndrome.