We found that two of these genes, COL6A3 and ITGB5, as well as TNC and COL5A2 are significantly expressed relative to background in module 3 and are associated with the focal adhesion-PI3K-Akt signaling axis in canine osteosarcoma as seen in Fig 8 and S7 File. The gene discussed is ITGB5; the disease is osteosarcoma.