AKT1 and cancer: CD44 and its multiple splice variants are involved in a variety of cancer mechanisms, [63] including angiogenesis via the ERM-VEGFR axis, cell proliferation via the ERM-VEGFR-MAPK axis, metabolic shift in cancer cells via the SRC-AKT axis, and cancer cell invasion via the HGF-MET-PI3K-AKT axis.