CD8A and type 1 diabetes mellitus: The objective of therapy-directed simulations is to test the following hypothesis: the occurrence of T1D is significantly delayed or inhibited by therapeutic interventions if: 1) the lifespan of CTLs in islets was reduced; 2) the capacity of naïve CD8+ T cell binding to DCs was reduced; 3) the recruitment rate of DCs was reduced; or 4) two of the above strategies (1)-(3) were applied simultaneously by a combination of these therapeutic interventions.