Thus, unlike single-drug interventions, the effect of combined therapeutic strategies (e.g. a combination of treatment strategy on reducing both recruitment rate of DCs and number of binding sites on DCs for naïve CD8+ T cells) on T1D treatment may provide valuable insight into a prospective cross-sectional as well as longitudinal studies of onset, remission, and recurrence. Here, CD8A is linked to type 1 diabetes mellitus.