CD8A and type 1 diabetes mellitus: Moreover, results from therapy-directed simulations suggest that a combination of therapeutic strategy on reducing both recruitment rate of DCs and the maximum number of naïve CD8+ T cells binding to DCs would noticeably reverse the mechanism of destruction of beta cells, a potential to cure overt T1D, from week 10 to week 12 (as plotted in the heatmaps of Fig 9 and S5 Fig).