RSPO1 and hereditary disease: While no other biallelic variants in SNIP1 have conclusively been associated with genetic disease to date, Jacher and Innis (2018) reported a 17-year-old female with a de novo 2.3 Mb interstitial deletion at 1q34.3q34.2 that encompassed 43 genes, of which only two (SNIP1 and RSPO1) were potentially linked with genetic disease genes at the time of publication [15].