Other GDAs associated with known DS comorbidities included GALC and seizures; GJA1 and cancer, hypertensive disease, heart anomalies; S100B, associated with schizophrenia, myocardial infarction, mental depression and bipolar disorders; and DDX58 and infection that would reflect the higher susceptibility to infection for DS patients [22]. Here, S100B is linked to bipolar disorder.