WWOX and Down syndrome: The green module was enriched in extracellular matrix (integrin), amyloid-beta, neutrophil degranulation, and synaptic cleft; the blue module in RAGE ("receptor for advanced glycation end products"), glucocorticoid, hydroxymethyl, formyl, and Down syndrome; the orange module extracellular matrix, negative regulation of neuronal differentiation, cognition, aging; and finally the yellow module contained many up-regulated genes enriched in interferon response, innate immune response, neuron recognition, ubiquitin, virus, NFkB signaling, and cytokine signaling.