Currently, more BC predisposition genes have been identified, including genes with high penetration (TP53, CDH1, PTEN, and STK11), moderate penetration (PALB2, CHEK2, ATM, NBN, etc.), and low penetration (MLH1, MSH2, MSH6, PMS2, MEN1, etc.)12–14. This evidence concerns the gene MSH6 and breast cancer.