Cox regression survival analysis showed that elevated p-PYK2 was an independent adverse predictor for OS [hazard ratio (HR) = 3.304, P = 0.003] (Figure 7E) and PFS (HR = 2.930, P < 0.001) (Figure 7F) in the 115 patients with melanomas (Supplementary Table S2). Here, PTK2B is linked to melanoma.