With regards to the potential of chemoprevention, current findings suggest that the osteoprotegerin (OPG)/receptor activator of nuclear factor (NF)-κB (RANK)/ RANK ligand (RANKL) pathway, a key regulator in bone metabolism, plays a crucial role in the tumorigenesis of gBRCA1/2-associated BC [8–13]. Here, TNFRSF11B is linked to breast cancer.