The RANK/RANKL cascade might provide potential targets for chemoprevention for gBRCA1/2-associated BC [19], especially since the pathway seems hyperactivated in gBRCA1/2 mutation carriers leading to massively elevated RANKL expression [20–22] as well as notably lower levels of serum OPG [23–26]. The gene discussed is TNFRSF11B; the disease is breast cancer.