With regards to the potential of chemoprevention, current findings suggest that the osteoprotegerin (OPG)/receptor activator of nuclear factor (NF)-κB (RANK)/ RANK ligand (RANKL) pathway, a key regulator in bone metabolism, plays a crucial role in the tumorigenesis of gBRCA1/2-associated BC [8–13]. This evidence concerns the gene TNFRSF11A and breast cancer.