Recent studies have revealed a tight link between neurodegenerative diseases, particularly Parkinson’s disease, and proteins that participate in synaptic vesicle endocytosis, such as auxilin (Song et al., 2017), synaptojanin 1 (Cao et al., 2017), and endophilin (Trempe et al., 2009). The gene discussed is SYNJ1; the disease is neurodegenerative disease.