Subsequently, the expression levels of GPR17 and Olig1 in rats were measured in the sham, PVL, NC, GPR17-overexpressed, and siR-GPR17 groups on days 1, 3, and 7 after PVL modeling, respectively, accompanied by observation of myelin regeneration and repair after PVL white matter injury using TEM. This evidence concerns the gene GPR17 and periventricular leukomalacia.