Because the expression of a large number of pro‐atherogenic genes was attenuated by the ERK1−/− and STAT1 S727A genetic modifications, their effects on several macrophage processes associated with atherosclerosis was investigated using BMDM from C57BL/6J, ERK1−/−, and STAT1 S727A mice. The gene discussed is MAPK3; the disease is atherosclerosis.