The exact role of spleen in atherogenesis is not fully understood although increased spleen size has been associated with decreased atherosclerosis and plaque development in LDLR−/− mice42 and splenectomy increases atherosclerotic lesions in ApoE−/− mice due to loss of B‐cell‐associated protective immunity.43, 44. The gene discussed is APOE; the disease is atherosclerosis.