TP53 and neoplasm: Although p53 is an established suppressor of proliferation in response to aneuploidy, mutations in TP53 correlate consistently and most strongly with aneuploidy and WGD in multiple tumour types (Bielski et al., 2018; Ciriello et al., 2013; Davoli et al., 2017; Taylor et al., 2018; Thompson and Compton, 2010; Zack et al., 2013).