In contrast, loss of macrophage TLR4 resulted in the shift of macrophages from M1 to M2-predominant phenotype, thereby suppressing the immunogenicity of MHC class II expressing macrophages and redirecting T cell immune responses from Th1/Th17 towards Treg to protect against anti-GBM GN. The gene discussed is TLR4; the disease is glioblastoma.