Here we found that deficiency of myeloid TLR4 largely reduced the MHC II expression by macrophages infiltrating the kidney in tlr4f/f–lysM−Cre mice as compared to those in tlr4f/f mice at both days 7 and day 14 after anti-GBM GN induction (Fig. 4E). This evidence concerns the gene TLR4 and glioblastoma.