Thus, macrophage TLR4 may not only function as a key regulator for macrophage polarization and activation but may also play a regulatory role in bridging the innate and adaptive immune response by activating MHC-expressing macrophages to present antigens to the T cells and promoting the Th1/Th17-dependent anti-GBM GN. This evidence concerns the gene HLA-C and ganglioneuroma.