The further enrichment analysis of all the mutated genes revealed that they were markedly enriched in multiple AML-related signaling pathways, which consisted of PI3K-Akt signaling pathway, Ras signaling pathway, MAPK signaling pathways, etc., and the known chronic myeloid leukemia-related signaling pathways as well as AML-related signaling pathways (Fig. 8). This evidence concerns the gene AKT1 and acute myeloid leukemia.