According to the data of Oncomine database, BCL2 is markedly upregulated in the cell lines of leukemia compared to other malignancies (Fig. 1A) and is also increased in relapsed leukemia patients (Fig. 1B) and dead leukemia patients (Fig. 1C), which has allowed the use of venetoclax in the leukemia patients; meanwhile, its clinical application in AML treatment is also introduced [9, 10]. Here, BCL2 is linked to leukemia.