Additionally, previous studies using the disease model for multiple sclerosis in mice, experimental autoimmune encephalomyelitis, demonstrate that macrophages and microglia release Hgf and OPCs upregulate Met signaling in response to demyelinated legions (Lalive et al. 2005; Moransard et al. 2009). The gene discussed is MET; the disease is experimental autoimmune encephalomyelitis.