ORC4 and Meier-Gorlin syndrome: Identification of missense mutation in ORC4, Y174C in humans is reported in Meier-Gorlin syndrome (Bicknell et al., 2011, Guernsey et al., 2011) whereas in yeast, ORC4 mutation, Y232C resulted in slower growth rate with G1 to S phase transition defects (Ladha 2011) and locus specific chromosome breakage (Sanchez et al., 2017).