EGFR and neoplasm: Broadly, there were evidence of a monoclonal origin of tumor in the prostate given shared mutations [EGFR (R108K), PTPRT (H1408L), and ZNF292 (K2093E)] across all diagnostic biopsies (Fig 2 and Data Supplement) and evidence of whole-genome doubling (WGD) by allele-specific copy number analyses and two copies of the X chromosome in almost every tumor sample.