As a carrier of oncogene amplification, ecDNAs are subjected to non-Mendelian inheritance, which enables tumors to achieve very high intratumoral genetic heterogeneity and evolve rapidly in response to changing conditions (24, 66, 82)—for example, EGRF, MET, or MYC ecDNAs can make tumor cells proliferate rapidly and further develop into tumor invasion and migration (51, 66). The gene discussed is MET; the disease is neoplasm.