Interestingly, a knockout mouse model of TIMP3 also increased complications related to early ventricular wall thinning, with TIMP3−/− mice demonstrating lower hydroxyproline content, procollagen synthesis, and TGFβ expression 2 days post-MI as well as a 4-fold increase in cardiac rupture compared to wild-type mice (107). Here, TIMP3 is linked to myocardial infarction.