SFRP5 and myocardial infarction: Before MI, AAV9-NC and AAV9-Sfrp5 hearts had comparable chamber dimensions and ventricular function, but as early as 1 week post MI, AAV9-NC animals had a significantly greater decrease in LV ejection fraction (LVEF) and LV fractional shortening (LVFS) in comparison with AAV9-Sfrp5 animals, reflecting marked LV dysfunction in the AAV9-NC (Figures 3A–C).