Consistent with these GO analysis results, Up-trend DEGs include many genes related hearing loss such as MYO7A, CLRN1, WHRN, FSCN2, PCDH15, PLS1, CIB2, USH1C, THRB, and PTPRQ. On the other hand, in Down-trend DEGs expressed higher levels at the base, enriched GO terms include broad developmental and biological processes such as system development, multicellular organismal processes, and signal transduction. The gene discussed is CLRN1; the disease is hearing loss disorder.