ILF3 has been reported to function as a critical regulator for the serine-glycine one-carbon (SGOC) pathway in colorectal cancer (CRC) via EGFR-ERK axis followed by E3 ligase speckle-type POZ protein (SPOP)-mediated poly-ubiquitination and degradation of ILF3 (Li et al., 2020). Here, SPOP is linked to colorectal cancer.