Furthermore, a clinical trial in women with polycystic ovary syndrome, a disease that also has features of the metabolic syndrome, including insulin resistance, obesity, and a pro-inflammatory estate, demonstrated that Lactobacillus supplementation could reduce the inflammation through IL-6, CRP reduction, and increase of IL-10, in congruence with a decrease in weight and body mass index (36). Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.