CD4 and infection: In addition, Cox regression analysis showed that patients in low CD3+ (HR = 2.225, 95% CI: 1.289–3.841, p = 0.004), CD4+ (HR = 3.591, 95% CI: 1.870–6.896, p < 0.001), and CD4+/CD8+ ratio (HR = 4.507, 95% CI: 2.592–7.837, p < 0.001) T lymphocyte group had a greater risk of major infection than patients with normal level T lymphocyte group in multivariable-adjusted models (Table 2; Figure 3A).