Li et al. proved that Foxa1/a2 played essential roles in sexual dimorphism of HCC in 2012 (32) and Zhang et al. suggested that overexpression of nuclear androgen receptor driven by PI3K-AKT- mTOR pathway was associated with progression and prognosis of HCC in 2018 (33). Here, AKT1 is linked to hepatocellular carcinoma.