Cell division cycle 20 (CDC20), in combination with G2 and S-phase expressed 1 (GTSE1), proliferating cell nuclear antigen (PCNA), and minichromosome maintenance complex component 6 (MCM6), could have effects on cell cycle of HCC, while serving as markers for poor prognosis (5). This evidence concerns the gene GTSE1 and hepatocellular carcinoma.