AKT1 E17K mutation, identified from all primary and metastatic lesions in this PSP case, were localized to the pleckstrin homology domain (PH domain), which is crucial for membrane localization and downstream activation of AKT1 (18) and is known to promote growth factor-independent cell proliferation (19, 20). Here, AKT1 is linked to supranuclear palsy, progressive, 1.