For example, in CRC and hepatocellular cancer, TFR can be targeted by miRNAs including miR-22, miR-31, miR-141, miR-145, miR-152, miR-182, miR-200a, miR-320, miR-758, and miR19463–65, resulting in a disruption between TF and TFR and the following iron importing process (Zhang et al., 2020e). Here, TFRC is linked to colorectal carcinoma.