IREB2 and cancer: Meanwhile, the expression of iron metabolism-associated genes, including TRFC, FTH1, and FTL, can be modulated by the epigenetic silencing of the iron-responsive element binding protein 2 (IREB2) (Dixon et al., 2012), while other perturbations of mechanisms, including acetylation and methylation, have been observed to regulate iron metabolism in cancer cells by controlling transcript encoding proteins (Manz et al., 2016).