AKT1 and neoplasm: The results summarized in Figure 4 show that the ICB and lenvatinib target genes were implicated in multiple pathways associated with tumor development and progression (Supplementary Data 4), including the following terms: Ras signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, regulation of receptor signaling pathway via JAK-STAT, positive regulation of cell cycle.