At the cellular level, PLEKHA7 has been involved in the stabilization of cadherin-based junctions and TJ barrier function through the anchorage to microtubules (Meng et al., 2008; Paschoud et al., 2014), the junctional recruitment of RNA-interference machinery and the RNA-inducing silencing complex (RISC) to regulate signaling and cancer growth (Kourtidis et al., 2015, 2017; Nair-Menon et al., 2020), and the junctional recruitment of nectins and the Tspan-ADAM10 complex of transmembrane proteins (Guerrera et al., 2016; Shah et al., 2018). This evidence concerns the gene TSPAN18 and cancer.