PDZD11 and cyst: To investigate in more details the role of WW-PLEKHAs in the regulation of PDZD11, we analyzed the localization of endogenous and exogenous PDZD11, and the protein expression levels of endogenous PDZD11 in cells KO for WW-PLEKHAs, grown either in a 3D cyst culture model, or polarized on transwell filters.