TP53 and malignant colon neoplasm: A higher proportion of APC (80.7%) and TP53 (61.9%) mutations were found in the high-mRNAsi group than the proportion of APC (70.7%) and TP53 (51.2%) mutations in the low-mRNAsi group of colon cancer patients, and the difference was statistically significant (Supplementary Figures 2, 3).