CUEDC2 and brain ischemia: Otake et al. (2019) found 543 dysregulated mRNAs in ALS patient CSF exosomes compared to healthy controls. Among these, CUE domain-containing 2 (CUEDC2) protein was suggested as a potential ALS biomarker. Interestingly, CUEDC2 has been evidenced to play an important role in cerebral ischemia (Huang et al., 2021).