In addition to the most commonly found SOD1 and TDP-43 proteins, comprehensive proteomic analyses of exosomes have also found a number of less studied proteins associated with ALS including FUS mutations, aberrant hexanucleotide repeat expansions in C9orf72, and inflammation-related factors Interleukin-6 (IL-6) (Kamelgarn et al., 2016; Westergard et al., 2016; Chen B. Y. et al., 2019). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.