However, the increase of Th1 and Th17 cells in the BD-recipient mice might lead to an augmented secretion of pro-inflammatory cytokines including IFN-γ, TNF- α, IL-6 and IL-17 that may contribute to the development of disease (Tang et al., 2009; Pattarini et al., 2017). This evidence concerns the gene IL17A and Behcet disease.