Zhou et al. (2020a) demonstrated that oltipraz activates the Nrf2–HO-1 signaling pathway and may attenuate paclitaxel-induced neuralgia. PPARγ activation was shown to induce the Nrf2–HO-1 signaling pathway, thereby alleviating mechanical allodynia in paclitaxel-induced neuralgia (Zhou et al., 2020b). This evidence concerns the gene HMOX1 and neuralgia.