As previously reported, CCNE2, which is frequently observed in proliferation, or migration in various kinds of cancers, is one of the two regulatory subunits of cyclin-dependent kinase 2 and could regulate the progression from G1 to S phase in cells (Sonntag et al., 2018; Sun et al., 2020; Wu D. et al., 2020). Here, CCNE2 is linked to cancer.