However, similar to ABHD2, NGF signaling does not only regulate the function of the interstitial cells but can also affect the maturation of granulosa cells, as seen in a mouse model with excess expression of Ngf. The Ngf overexpressors present with increased antral formation and apoptosis of granulosa cells, which leads to a PCOM phenotype without the formation of ovarian cysts (Dissen et al., 2009; Wilson et al., 2014). Here, NGF is linked to Ovarian cyst.