ABHD2 and polycystic ovary syndrome: We show that ABHD2 is needed to regulate the cyclic maturation of follicles, where ablation of Abhd2 gives rise to a phenotype similar to that of polycystic ovary morphology (PCOM) with irregular menstrual cycles and an increased number of atretic follicles, but without the fertility issues associated with polycystic ovary syndrome (PCOS).