Sun et al. (2017) found that lncRNA HOTAIR regulated cisplatin-resistance and autophagy by targeting Beclin-1, MDR, and P-GP in endometrial cancer cells. Finally, Liu C. et al. (2020) showed that lncRNA RMST was overexpressed in clinical glioma samples. RMST inhibited autophagy in glioma cells by inducing SUMO1 modification at K333 of FUS. SUMOylation of FUS promotes the degradation of ATG4D, a regulator of autophagy. More advances in the regulation of autophagy by lncRNAs in tumors are summarized in Table 2. The gene discussed is ATG4D; the disease is central nervous system cancer.