In addition to inhibiting the RAF/MEK/ERK signaling pathway, Sorafenib tosylate significantly inhibits the phosphorylation of eIF4E and down-regulates the level of Mcl-1 in liver cancer (HCC) cells in a MEK/ERK-dependent manner, and induces significant apoptosis (Liu et al., 2006). The gene discussed is MAP2K7; the disease is hepatocellular carcinoma.