Furthermore, TSC2, LKB1, P53, P21, PTEN, caspase 7, caspase 3 expressing states were increased and the expression of Bcl-2, cyclin D1, c-FLIP were declined in NSCLC cells and slc10a2 overexpressed NSCLC cells with the treating process of Bexarotene. The gene discussed is TP53; the disease is non-small cell lung carcinoma.