TGFB1 and Hepatic fibrosis: TGF-β plays an important role during all phases of the development of liver fibrosis, being responsible for hepatic stellate cell (HSC) activation to myofibroblasts (MFBs) (Fabregat and Caballero-Díaz, 2018), reactive oxygen species (ROS) generation (Liu and Desai, 2015), and ECM production stimulation (Verrecchia and Mauviel, 2007).