CD4 and neoplasm: Akkermansia muciniphila was correlated with increased immune cell infiltration in lung and kidney cancers, as CCR9+CXCR3+CD4+ T cells were recruited to the tumor bed in an interleukin-12-dependent manner and the ratio of CD4+ T cells to CD4+FoxP3+ T cells (Tregs) was increased (Routy et al., 2018).