Experimental results have shown that triclosan can disrupt the intestinal barrier function in the body, increase immune cell infiltration, cause the transfer of TLR4 ligands (such as lipopolysaccharides and other bacterial products) from the intestinal tract to the systemic circulation, and promote the activation of TLR4 signal, thus promoting the occurrence and development of colitis and colon cancer (Thaiss et al., 2016; Yang et al., 2018). The gene discussed is TLR4; the disease is malignant colon neoplasm.