Cryptococcosis occurs under CD4+ T cell immunodeficiency and our previous work showed that immunization of a CD4+ deficient host with C. neoformans Δsgl1 mutant accumulating sterylglucosides (SGs) conferred total protection against a lethal challenge with the highly virulent C. neoformans wild-type (WT) H99 strain (Rella et al., 2015). Here, CD4 is linked to cryptococcosis.