Nonetheless, because we show that either CD4+ or CD8+ T cells are required, C. neoformans Δsgl1 still remains a viable option for the major risk factors during the opportunistic infection with C. neoformans since CD8+ T cells remain accessible during CD4-lymphopenia (Collins et al., 2020; Akhtar et al., 2020; Linyu et al., 2020). Here, CD4 is linked to Opportunistic infection.