FGD5 and cervical cancer: Chlamydia can cooperate with HPV to induce cervical cancer and activate Wnt signaling pathway in Ishikawa and Hec-1b cell lines, as well as fallopian tube tissue, suggesting that Ct upregulates FGD5-AS1 to inhibit apoptosis via Wnt signaling pathway, which may be the general mechanism of Ct pathogenesis (Kessler et al., 2012; Kintner et al., 2017).