FGD5-AS1 has been reported to regulate signaling pathways by regulating different molecules in different cancer cells such as colorectal cancer cells, esophageal squamous cell carcinoma cells, and non-small-cell lung cancer cells, so as to promote the proliferation and migration of these cancer cells (Li et al., 2019; Fan et al., 2020; Gao et al., 2020). The gene discussed is FGD5; the disease is esophageal squamous cell carcinoma.