STAT3 and primary cutaneous T-cell non-Hodgkin lymphoma: Moreover, it has been demonstrated that cutaneous T cell lymphoma patients are frequently colonized with S. aureus expressing staphylococcal enterotoxins (SEs) that induce crosstalk between malignant and benign T cells, leading to Stat3-mediated interleukin-10 production by malignant T cells, which has an important role in driving immune dysregulation and severe immunodeficiency (Krejsgaard et al., 2014).