NLRP3 and endothelial dysfunction: Chen et al. (2020) in their experimental study confirmed that testosterone therapy reduces atherogenesis by suppressing NLRP3 inflammasome. However, Alves et al. (2020) showed that supra-physiological testosterone level leads to oxidative stress-induced endothelial dysfunction and vascular injury through stimulation of NLRP3 inflammasome. Previously, Vignozzi et al. (2012) disclosed that testosterone through its derivative dihydrotestosterone suppresses NF-κB signaling activation and associated pro-inflammatory activations.