Schroeder et al. (2020) illustrated that low testosterone serum level is linked to SARS-CoV-2 infections and COVID-19 severity in critically ill patients due to reduced immunomodulation antiviral effects of androgen. On the other hand, Wambier et al. (2020) revealed that high testosterone and other androgens serum levels might increase the severity of COVID-19 through augmentation of the expression of transmembrane protease serine 2 (TMPRSS2), which is vital for cleaving and activation of SARS-CoV-2 spike protein during acute SARS-CoV-2 infection. This evidence concerns the gene TMPRSS2 and COVID-19.