Thereby, TMPRSS2 inhibitors such as bromhexine, aprotinin, camostat, and nafamostat are useful in managing COVID-19 through attenuation of TMPRSS2-dependent lung inflammation, coagulopathy, and development of ARDS (Azimi, 2020; Breining et al., 2020). The gene discussed is TMPRSS2; the disease is COVID-19.